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Single-Use Bioreactor Systems

Thu, 12/01/2011 - 10:24am

Integrity™ Xpansion™ Bioreactor Systems
ATMI, Inc.’s Integrity™ Xpansion™ bioreactor systems enable large-scale, cell-based manufacturing. According to the company, the bioreactors:
  • Have been especially developed for fragile, adherent cell culture applications (such as stem cells), on a large scale.
  • Support safe and cost-efficient large-scale (large volume) production of traditional two-dimensional (2-D) cell cultures with the advantage of cell culture parameter controls.
  • Feature the 2-D multi-plate design, which offers the same cell environment as standard multi-tray technology, but adds the benefit of a closed system for increased protection from potential contamination.
  • Do not change critical cell culture parameters, successfully mitigating risk during process scale-up for large clinical studies.
  • Offer easy transition from existing technologies to the Xpansion systems, at any stage of a clinical study.
  • Offer quick scale-up to process design for flexibility and speed in both upstream and downstream processing.
  • Dramatically reduce the number of operations needed, maximizing safety and reducing the cost of goods by up to 40 percent.
  • Feature a design that ensures sterility and reduces the risk of contamination.
  • Allow for the cell culture parameters (including pH, DO, and temperature) to be read using real-time controls in order to allow process reproducibility and traceability.
  • Monitor and control temperature, dissolved oxygen, pH, and media flow rate.
  • Integrate with the full line of ATMI technologies, including the Integrity™ brand of single-use technologies, ranging from mixers to bioprocess vessels and bags.
  • Are of stacked polystyrene plates within a closed system; up to 180 of these plates can be stacked to produce a unit with a surface area of 11m2, and, as the plates are close together (just 1.6mm apart), the entire bioreactor is about 60cm high and is 35cm in diameter, resulting in a completely closed, single-use bioreactor, from vessel to sensor.

 

www.atmi-lifesciences.com

 

 

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