High Efficacy of {beta}-Blockers in Long-QT Syndrome Type 1. Contribution of Noncompliance and QT-Prolonging Drugs to the Occurrence of {beta}-Blocker Treatment "Failures"

Tue, 07/27/2010 - 7:38am
Background--{beta}-Blocker efficacy in long-QT syndrome type 1 is good but variably reported, and the causes of cardiac events despite {beta}-blocker therapy have not been ascertained.Methods and Results--This was a retrospective study of the details surrounding cardiac events in 216 genotyped long-QT syndrome type 1 patients treated with {beta}-blocker and followed up for a median time of 10 years. Before {beta}-blocker, cardiac events occurred in 157 patients (73%) at a median age of 9 years, with cardiac arrest (CA) in 26 (12%). QT-prolonging drugs were used by 17 patients; 9 of 17 (53%) had CA compared with 17 of 199 nonusers (8.5%; odds ratio, 12.0; 95% confidence interval, 4.1 to 35.3; P<0.001). After {beta}-blocker, 75% were asymptomatic, and cardiac events were significantly reduced (P<0.001), with a median event count (quartile 1 to 3) per person of 0 (0 to 1). Twelve patients (5.5%) suffered CA/sudden death, but 11 of 12 (92%) were noncompliant (n=8), were on a QT-prolonging drug (n=2), or both (n=1) at the time of the event. The risk for CA/sudden death in compliant patients not taking QT-prolonging drugs was dramatically less compared with noncompliant patients on QT-prolonging drugs (odds ratio, 0.03; 95% confidence interval, 0.003 to 0.22; P=0.001). None of the 26 patients with CA before {beta}-blocker had CA/sudden death on {beta}-blockers.Conclusions--{beta}-Blockers are extremely effective in long-QT syndrome type 1 and should be administered at diagnosis and ideally before the preteen years. {beta}-Blocker noncompliance and use of QT-prolonging drug are responsible for almost all life-threatening "{beta}-blocker failures." {beta}-Blockers are appropriate therapy for asymptomatic patients and those who have never had a CA or {beta}-blocker therapy. Routine implantation of cardiac defibrillators in such patients does not appear justified.


Share this Story

You may login with either your assigned username or your e-mail address.
The password field is case sensitive.