Aug 29
Resource limitations, such as the availability of soil nitrogen (N), are expected to constrain continued increases in plant productivity under elevated atmospheric carbon dioxide (CO(2)). One potential but under-studied N source for supporting increased plant growth under...
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Aug 7
The discovery of ribozymes led to the proposal of an RNA world, where a single type of molecule was supposedly capable of self-replication and chemical catalysis. We show here that both autocatalysis and organocatalysis can be engineered into a synthetic structure. The compound...
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Aug 5
Membrane and protein traffic to the cell surface is mediated by partially redundant pathways that are difficult to perturb in ways that yield a strong phenotype. Such robustness is expected in a fine-tuned process, regulated by environmental cues, that is required for...
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Aug 4
The efficacy of synaptic transmission depends on the maintenance of a high density of neurotransmitter receptors and their associated scaffold proteins in the postsynaptic membrane. While the dynamics of receptors has been extensively studied, the dynamics of the intracellular...
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Jul 27
Background--{beta}-Blocker efficacy in long-QT syndrome type 1 is good but variably reported, and the causes of cardiac events despite {beta}-blocker therapy have not been ascertained.Methods and Results--This was a retrospective study of the details surrounding cardiac events...
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Jul 10
To clarify the causes of low oral bioavailability (BA) of drugs in cynomolgus monkeys, the experimental method to evaluate the drug permeability and the metabolism in the intestine of cynomolgus monkeys was established. An in situ intestinal perfusion method was performed with...
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Mar 24
The effect of caffeine complexation with riboflavin on the kinetics of riboflavin photolysis in the pH range 2.0-10.5 has been studied. The photolysis of riboflavin solutions (5x10(-5) M) was carried out in the presence of caffeine (0.5-2.5x10(-4) M) using a visible radiation...
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Feb 10
The increasing structural information about target-bound compounds provide a rich basis to study the binding mechanisms of metabolites and drugs. SuperSite is a database, which combines the structural information with various tools for the analysis of molecular recognition. The...
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Feb 10
MMsINC (http://mms.dsfarm.unipd.it/MMsINC/search) is a database of non-redundant, richly annotated and biomedically relevant chemical structures. A primary goal of MMsINC is to guarantee the highest quality and the uniqueness of each entry. MMsINC then adds value to these...
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Feb 10
Protein kinase B (PKB or Akt) is a central component of the PI3K - PKB - mTOR signalling cascade and is firmly established as an attractive target for pharmacological intervention in cancer. A number of small molecule inhibitors with well-defined, direct molecular interactions...
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