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SuperSite: dictionary of metabolite and drug binding sites in proteins.

February 10, 2010 1:38 pm | by Nucleic Acids Res | Articles | Comments

The increasing structural information about target-bound compounds provide a rich basis to study the binding mechanisms of metabolites and drugs. SuperSite is a database, which combines the structural information with various tools for the analysis of molecular recognition. The...

MMsINC: a large-scale chemoinformatics database.

February 10, 2010 1:38 pm | by Nucleic Acids Res | Articles | Comments

MMsINC (http://mms.dsfarm.unipd.it/MMsINC/search) is a database of non-redundant, richly annotated and biomedically relevant chemical structures. A primary goal of MMsINC is to guarantee the highest quality and the uniqueness of each entry. MMsINC then adds value to these...

Targeted small-molecule inhibitors of protein kinase B as anticancer agents.

February 10, 2010 1:38 pm | by Anticancer Agents Med Chem | Articles | Comments

Protein kinase B (PKB or Akt) is a central component of the PI3K - PKB - mTOR signalling cascade and is firmly established as an attractive target for pharmacological intervention in cancer. A number of small molecule inhibitors with well-defined, direct molecular interactions...

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[Medicines used for and with children. No, I don't need my drops!]]

February 10, 2010 1:38 pm | by Pharm Unserer Zeit | Articles | Comments

Deducing in vivo toxicity of combustion-derived nanoparticles from a cell-free oxidative potency assay and metabolic activation of organic compounds.

February 10, 2010 1:38 pm | by Environ Health Perspect | Articles | Comments

BACKGROUND: The inhalation of combustion-derived nanoparticles (CDNPs) is believed to cause an oxidative stress response, which in turn may lead to pulmonary or even systemic inflammation. OBJECTIVE AND METHODS: In this study we assessed whether the in vivo inflammatory...

Oral administration of pharmacologically active substances to squid: a methodological description.

February 10, 2010 1:38 pm | by Biol Bull | Articles | Comments

The squid giant synapse is a well-defined experimental preparation for the study of ligand-dependant synaptic transmission. Its large size gives direct experimental access to both presynaptic and postsynaptic junctional elements, allowing direct optical, biophysical, and...

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An examination of existing data for the industrial manufacture and use of nanocomponents and their role in the life cycle impact of nanoproducts.

February 10, 2010 1:38 pm | Articles | Comments

This work examines the manufacture and use of nanocomponents and how they can affect the life cycle impact of resulting nanoproducts. Available data on the production of nanoproducts and nanocomponents are used to identify the major groups of nanocomponents studied in this...

Criminal Probe Is Launched in Conn. Plant Blast

February 10, 2010 12:25 pm | by AssociatedPress | Videos | Comments

Authorities launched a criminal investigation Monday into the cause of an explosion that killed five people at a power plant under construction, saying they couldn't rule out negligence. (Feb. 8)

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Kleen Energy Accident Investigation

February 10, 2010 12:25 pm | by WTNH | Videos | Comments

Images of the damaged plant and details of the investigation into how gas purging operations resulted in such a catastrophic explosion.

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Renewable Energy Wants Extensions for Tax Credits

February 10, 2010 12:24 pm | by CleanSkiesNews | Videos | Comments

Renewable energy leaders held a conference call Tuesday, Feb. 8, to discuss their legislative priorities for 2010. They want the tax credits contained in the Recovery Act to be extended for at least three years to encourage private financing and investment in renewable energy projects....

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The Solution to Everything — Charge More

February 10, 2010 6:19 am | by DAVID MANTEY, Editor, Product Design & Development (PD&D) | Blogs | Comments

Some companies seem to have quit trying to find a new model or improve an old one. They are willing to ride increasing fees into the bankruptcy sunset across the scorched customer service plains.

X-Ray Inspection System Implementation

February 9, 2010 12:04 pm | Articles | Comments

Contract Pharmacal Corporation recently installed five SmartChek x-ray inspection systems on its packaging lines.

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UL Listed Segment Protectors

February 9, 2010 10:52 am | Product Releases | Comments

Pepperl + Fuchs’ R2 FieldConnex® Segment Protectors are now UL listed for Div 2 applications.

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